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Baseline hemoglobin A1C was around 5.7% in the STEP 1 and STEP 3 studies, 5.5% in the STEP 8 study, and 5.4% in the STEP 4 study, and much higher (8.1%) in the STEP 2 study, which enrolled patients with type 2 diabetes

This benefit appeared independent of weight loss, suggesting direct cardiovascular protective effects from GLP-1 receptor activation

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